It is typically characterized by jaundice, coagulopathy and encephalopathy resulting from sudden hepatic dysfunction without preexisting liver disease.

In this context of liver injury and neurological dysfunction, we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.Д¬ONCLUSION: In summary, we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans, which may provide new insights for treatment.ДЄcute liver failure (ALF) is a rare but severe clinical syndrome. In agreement with this, neuropsychomotor abnormalities ensued 36 h after TAA, fulfilling several HE features observed in humans. Furthermore, TAA-treated mice presented with increased serum and cerebral levels of ammonia, in parallel with alterations in EEG spectrum and discrete brain edema, as shown by magnetic resonance imaging. This led to mice mortality and weight loss, which was associated with severe coagulopathy. An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury. RESULTS: Mice submitted to the TAA regime developed massive liver injury, as shown by elevation of serum ALT levels and a high degree of liver necrosis. Brain edema was evaluated using magnetic resonance imaging. Electroencephalography (EEG) and psychomotor activity score were performed to show brain function. Ammonia levels were quantified in serum and brain samples. Hemodynamic parameters were measured through tail cuff. Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time. Neutrophil infiltration was estimated by confocal liver intravital microscopy. Liver injury was assessed by serum transaminase levels (ALT) and liver histology (hematoxylin and eosin). METHODS: Mice received two consecutive intraperitoneal injections of thioacetamide (TAA) at low dosage (300 mg/kg). AIM: To propose an alternative model of hepatic encephalopathy (HE) in mice, resembling the human features of the disease.

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